Acquisition of motion events in L2 Spanish by German, French and Italian speakers

This article explores the second language acquisition of motion events, with particular regard to cross-linguistic influence between first and second languages. Oral narratives in Spanish as a second language by native speakers of French, German and Italian are compared, together with narratives by native Spanish speakers. Previous analysis on the expression of motion events in these languages showed that Romance languages do not always follow the same pattern; for example, Italian tends to express the component of Path more frequently than French and Spanish. The results of the present study highlight evidence of intra-typological differences, even between languages that are genetically very close. These differences seem to lead speakers to produce cases of conceptual transfer into their second language, Spanish, even when their first language is another Romance language

Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA

IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases

IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) may have protective properties in cardiovascular and rheumatic diseases. We here compare these antibodies in systemic rheumatic conditions and study their properties. Anti-PC and anti-MDA was measured using ELISA in patients with SLE (374), RA (354), Mixed connective tissue disease (MCTD, 77), Systemic sclerosis (SSc, 331), Sj\uf6gren\u2019s syndrome (SjS, 324), primary antiphospholipid syndrome (PAPs, 65), undifferentiated connective tissue disease (UCTD, 118) and 515 matched healthy controls (HC). Cardiovascular score (CV) was broadly defined based on clinical disease symptoms. Anti-PC and anti-MDA peptide/protein characterization were compared using a proteomics de novo sequencing approach. anti-MDA and anti-PC were extracted from total IgM. The proportion of Treg cells was determined by flow cytometry. The maximal difference between cases and controls was shown for MCTD: significantly lower IgM Anti-PC but not anti-MDA among patients (median 49.3RU/ml vs 70.4 in healthy controls, p(t-test) = 0.0037). IgM low levels were more prevalent in MCTD, SLE, SjS, SSc and UCTD. IgM anti-PC variable region profiles were different from and more homologous than anti-MDA. Anti-PC but not anti-MDA were significantly negatively correlated with CV in the whole patient group. In contrast to IgM anti-PC, anti-MDA did not promote polarization of Tregs. Taken together, Anti-PC is decreased in MCTD and also in SLE, SjS and SSc but not in other studied diseases. Anti-PC may thus differentiate between these. In contrast, anti-MDA did not show these differences between diseases studied. Anti-PC level is negatively correlated with CV in the patient group cohort. In contrast to anti-PC, anti-MDA did not promote Treg polarization. These findings could have both diagnostic and therapeutic implications, one possibility being active or passive immunization with PC in some rheumatic conditions

Validation of standardized data formats and tools for ground-level particle-based gamma-ray observatories

Ground-based gamma-ray astronomy is still a rather young field of research,with strong historical connections to particle physics. This is why mostobservations are conducted by experiments with proprietary data and analysissoftware, as it is usual in the particle physics field. However in recentyears, this paradigm has been slowly shifting towards the development and useof open-source data formats and tools, driven by upcoming observatories such asthe Cherenkov Telescope Array (CTA). In this context, a community-driven,shared data format (the gamma-astro-data-format or GADF) and analysis toolssuch as Gammapy and ctools have been developed. So far these efforts have beenled by the IACT community, leaving out other types of ground-based gamma-rayinstruments.We aim to show that the data from ground particle arrays, such asthe High-Altitude Water Cherenkov (HAWC) observatory, is also compatible withthe GADF and can thus be fully analysed using the related tools, in this caseGammapy. We reproduce several published HAWC results using Gammapy and dataproducts compliant with GADF standard. We also illustrate the capabilities ofthe shared format and tools by producing a joint fit of the Crab spectrumincluding data from six different gamma-ray experiments. We find excellentagreement with the reference results, a powerful check of both the publishedresults and the tools involved. The data from particle detector arrays such asthe HAWC observatory can be adapted to the GADF and thus analysed with Gammapy.A common data format and shared analysis tools allow multi-instrument jointanalysis and effective data sharing. Given the complementary nature of pointingand wide-field instruments, this synergy will be distinctly beneficial for thejoint scientific exploitation of future observatories such as the SouthernWide-field Gamma-ray Observatory and CTA.<br

Study of the Very High Energy emission of M87 through its broadband spectral energy distribution

The radio galaxy M87 is the central dominant galaxy of the Virgo Cluster.Very High Energy (VHE,$\gtrsim 0.1$ TeV) emission, from M87 has been detectedby Imaging Air Cherenkov Telescopes (IACTs ). Recently, marginal evidence forVHE long-term emission has also been observed by the High Altitude WaterCherenkov (HAWC) Observatory, a gamma ray and cosmic-ray detector array locatedin Puebla, Mexico. The mechanism that produces VHE emission in M87 remainsunclear. This emission is originated in its prominent jet, which has beenspatially resolved from radio to X-rays. In this paper, we constructed aspectral energy distribution from radio to gamma rays that is representative ofthe non-flaring activity of the source, and in order to explain the observedemission, we fit it with a lepto-hadronic emission model. We found that thismodel is able to explain non-flaring VHE emission of M87 as well as an orphanflare reported in 2005.<br

Gamma/Hadron Separation with the HAWC Observatory

The High Altitude Water Cherenkov (HAWC) gamma-ray observatory observesatmospheric showers produced by incident gamma rays and cosmic rays with energyfrom 300 GeV to more than 100 TeV. A crucial phase in analyzing gamma-raysources using ground-based gamma-ray detectors like HAWC is to identify theshowers produced by gamma rays or hadrons. The HAWC observatory records roughly25,000 events per second, with hadrons representing the vast majority($>99.9\%$) of these events. The standard gamma/hadron separation technique inHAWC uses a simple rectangular cut involving only two parameters. This workdescribes the implementation of more sophisticated gamma/hadron separationtechniques, via machine learning methods (boosted decision trees and neuralnetworks), and summarizes the resulting improvements in gamma/hadron separationobtained in HAWC.<br

The TeV Sun Rises: Discovery of Gamma rays from the Quiescent Sun with HAWC

We report the first detection of a TeV gamma-ray flux from the solar disk (6.3$\sigma$), based on 6.1 years of data from the High Altitude Water Cherenkov (HAWC) observatory. The 0.5--2.6 TeV spectrum is well fit by a power law, dN/dE = $A (E/1 \text{ TeV})^{-\gamma}$, with $A = (1.6 \pm 0.3) \times 10^{-12}$ TeV$^{-1}$ cm$^{-2}$ s$^{-1}$ and $\gamma = -3.62 \pm 0.14$. The flux shows a strong indication of anticorrelation with solar activity. These results extend the bright, hard GeV emission from the disk observed with Fermi-LAT, seemingly due to hadronic Galactic cosmic rays showering on nuclei in the solar atmosphere. However, current theoretical models are unable to explain the details of how solar magnetic fields shape these interactions. HAWC's TeV detection thus deepens the mysteries of the solar-disk emission.Comment: 15 pages, 8 figures including supplementary material. Accepted for publication in Physical Review Letter

The CARMENES search for exoplanets around M dwarfs High-resolution optical and near-infrared spectroscopy of 324 survey stars

The CARMENES radial velocity (RV) survey is observing 324 M dwarfs to search for any orbiting planets. In this paper, we present the survey sample by publishing one CARMENES spectrum for each M dwarf. These spectra cover the wavelength range 520–1710 nm at a resolution of at least R >80 000, and we measure its RV, Hα emission, and projected rotation velocity. We present an atlas of high-resolution M-dwarf spectra and compare the spectra to atmospheric models. To quantify the RV precision that can be achieved in low-mass stars over the CARMENES wavelength range, we analyze our empirical information on the RV precision from more than 6500 observations. We compare our high-resolution M-dwarf spectra to atmospheric models where we determine the spectroscopic RV information content, Q, and signal-to-noise ratio. We find that for all M-type dwarfs, the highest RV precision can be reached in the wavelength range 700–900 nm. Observations at longer wavelengths are equally precise only at the very latest spectral types (M8 and M9). We demonstrate that in this spectroscopic range, the large amount of absorption features compensates for the intrinsic faintness of an M7 star. To reach an RV precision of 1 m s−1 in very low mass M dwarfs at longer wavelengths likely requires the use of a 10 m class telescope. For spectral types M6 and earlier, the combination of a red visual and a near-infrared spectrograph is ideal to search for low-mass planets and to distinguish between planets and stellar variability. At a 4 m class telescope, an instrument like CARMENES has the potential to push the RV precision well below the typical jitter level of 3–4 m s−1

Limits on the Diffuse Gamma-Ray Background above 10 TeV with HAWC

The high-energy Diffuse Gamma-Ray Background (DGRB) is expected to be produced by unresolved isotropically distributed astrophysical objects, potentially including dark matter annihilation or decay emissions in galactic or extragalactic structures. The DGRB has only been observed below 1 TeV; above this energy, upper limits have been reported. Observations or stringent limits on the DGRB above this energy could have significant multi-messenger implications, such as constraining the origin of TeV-PeV astrophysical neutrinos detected by IceCube. The High Altitude Water Cherenkov (HAWC) Observatory, located in central Mexico at 4100 m above sea level, is sensitive to gamma rays from a few hundred GeV to several hundred TeV and continuously observes a wide field-of-view (2 sr). With its high-energy reach and large area coverage, HAWC is well-suited to notably improve searches for the DGRB at TeV energies. In this work, strict cuts have been applied to the HAWC dataset to better isolate gamma-ray air showers from background hadronic showers. The sensitivity to the DGRB was then verified using 535 days of Crab data and Monte Carlo simulations, leading to new limits above 10 TeV on the DGRB as well as prospective implications for multi-messenger studies.Comment: 8 pages, 3 figure

The CARMENES search for exoplanets around M dwarfs HD147379 b: A nearby Neptune in the temperate zone of an early-M dwarf

We report on the first star discovered to host a planet detected by radial velocity (RV) observations obtained within the CARMENES survey for exoplanets around M dwarfs. HD 147379 (V = 8.9 mag, M = 0.58 ± 0.08 M⊙), a bright M0.0 V star at a distance of 10.7 pc, is found to undergo periodic RV variations with a semi-amplitude of K = 5.1 ± 0.4 m s−1 and a period of P = 86.54 ± 0.06 d. The RV signal is found in our CARMENES data, which were taken between 2016 and 2017, and is supported by HIRES/Keck observations that were obtained since 2000. The RV variations are interpreted as resulting from a planet of minimum mass mP sin i = 25 ± 2 M⊕, 1.5 times the mass of Neptune, with an orbital semi-major axis a = 0.32 au and low eccentricity (e < 0.13). HD 147379 b is orbiting inside the temperate zone around the star, where water could exist in liquid form. The RV time-series and various spectroscopic indicators show additional hints of variations at an approximate period of 21.1 d (and its first harmonic), which we attribute to the rotation period of the star.FEDER/ERF FICTS-2011-02 fundsMajor Research Instrumentation Programme and DFG Research Unit FOR2544 “Blue Planets around Red StarsEuropean Research Council (ERC-279347), Deutsche Forschungsgemeinschaft (RE 1664/12-1, RE 2694/4-1), Bundesministerium für Bildung und Forschung (BMBF-05A14MG3, BMBF-05A17MG3), Spanish Ministry of Economy and Competitiveness (MINECO, grants AYA2015-68012-C2-2-P, AYA2016-79425-C3-1,2,3-P, AYA2015-69350-C3-2-P, AYA2014-54348-C03- 01, AYA2014-56359-P, AYA2014-54348-C3-2-R, AYA2016-79425-C3-3-P and 2013 Ramòn y Cajal program RYC-2013-14875), Fondo Europeo de Desarrollo Regional (FEDER, grant ESP2016-80435-C2-1-R, ESP2015-65712-C5- 5-R), Generalitat de Catalunya/CERCA programme, Spanish Ministerio de Educación, Cultura y Deporte, programa de Formación de Profesorado Universitario (grant FPU15/01476), Deutsches Zentrum für Luft- und Raumfahrt (grants 50OW0204 and 50OO1501), Office of Naval Research Global (award no. N62909-15-1-2011), Mexican CONACyT grant CB-2012-183007